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The perform of SIK1 in tumorigenesis. SIK1 is actually a tumor suppressor gene, which performs a very important regulatory position in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and has an effect on cancer cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 may en